Atropine (sulfate) (Standard)

Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate) . This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia[1][2][3][4].

Product Specifications

CAS Number

[55-48-1]

Product Name Alternative

Tropine tropate (sulfate) (Standard) ; DL-Hyoscyamine (sulfate) (Standard) ; Sulfatropinol (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/atropine-sulfate-standard.html

Purity

98.40

Smiles

O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C(CO)C3=CC=CC=C3.[0.5H2SO4]

Molecular Formula

C17H23NO3.1/2H2SO4

Molecular Weight

338.41

Precautions

H302, H315, H319, H335

References & Citations

[1]McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33 (3) :373-8.|[2]Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33 (2) :441-57.|[3]Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59 (7) :2778-2791.|[4]Walch L, et, al. Evidence for a M (1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130 (1) :73-8.