GAK inhibitor 49 (hydrochloride)

GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2[1].

Product Specifications

CAS Number

[2930378-91-7]

UNSPSC

12352005

Target

Cyclin G-associated Kinase (GAK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gak-inhibitor-49-hydrochloride.html

Purity

99.52

Solubility

DMSO : 14.29 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C(OC)=CC(NC2=CC=NC3=CC(OC)=C(OC)C=C23)=C1.[H]Cl

Molecular Formula

C20H23ClN2O5

Molecular Weight

406.86

References & Citations

[1]Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13 (1) :48-66.