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NPPB antibody

Product Specifications

Background

NPPB, also known as B-type natriuretic peptide (BNP), is a cardiac hormone that is secreted mainly in the ventricles in response to increased wall stress. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. BNP is a marker of systolic and diastolic dysfunction and a strong predictor of mortality in heart failure patients.

Synonyms

Natriuretic peptides B|Brain natriuretic factor prohormone (preproBNP, proBNP) |Gamma-brain natriuretic peptide|Iso-ANP|NT-proBNP Alternative names: NT-pro-BNP|NT-proBNP (1-76) |proBNP (3-108) |Brain natriuretic peptide 32 (BNP (1-32), BNP-32) Alternative names: Brain natriuretic peptide (BNP) |BNP (1-30) |BNP (1-29) |BNP (1-28) |BNP (2-31) |BNP (3-32) Alternative names: des-SerPro-BNP|proBNP (79-108) |BNP (3-30) |BNP (3-29) |Brain natriuretic peptide 29 (BNP (4-32) ) |BNP (4-31) |BNP (4-30) |BNP (4-29) |BNP (4-27) |BNP (5-32) |BNP (5-31) |BNP (5-29) |NPPB

Gene ID

4879

UniProt

P16860

Host

Rabbit

Reactivity

Human

Immunogen

Natriuretic peptide precursor B

Target

NPPB

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IHC

Field of Research

Stem Cells, Cardiovascular

Purification

Immunogen affinity purified

Dilution

IHC: 1:20-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

15 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, IHC

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