Recombinant human MORF4L1 protein
MORF4L1 (mortality factor 4-like protein 1), also known as MRG15, belongs to the MRG family. This protein is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. MORF4L1 is a transcription factor expressed in a variety of human tissues, and its orthologs have been found in many other eukaryotes which constitute the MRG protein family. The C-terminal part of MRG15 forms a conserved MRG domain which is involved in interactions with the tumor suppressor protein retinoblastoma and a nucleoprotein. Recombinant human MORF4L1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Mortality factor 4-like protein 1, Eaf3, FWP006, HsT17725, MEAF3, MORFRG15, MRG15, S863-6
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
39.8 kDa (347aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Pardo P.S., et al. (2002) J. Biol. Chem. 277:50860-50866; ; Zhang P., et al. (2006) Protein Sci. 15:2423-2434
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 0.15M NaCl, 1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_006782
Uniprot Accession Number
Q9UBU8
Species
Human
AA Sequence
Frequently Asked Questions
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