MAP3K3 antibody
Product Specifications
Background
The mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases. (PMID: 18206350) .Cerebral cavernous malformations (CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.
Synonyms
Mitogen-activated protein kinase kinase kinase 3|MAPK/ERK kinase kinase 3 (MEK kinase 3, MEKK 3) |MAP3K3|MAPKKK3|MEKK3
Gene ID
4215
UniProt
Q99759
Host
Rabbit
Reactivity
Human
Immunogen
Mitogen-activated protein kinase kinase kinase 3
Target
MAP3K3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
74 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
