ZFP36L2 antibody
Product Specifications
Background
MRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510) . Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity) .
Synonyms
MRNA decay activator protein ZFP36L2|Butyrate response factor 2|EGF-response factor 2 (ERF-2) |TPA-induced sequence 11d|Zinc finger protein 36, C3H1 type-like 2 (ZFP36-like 2) |ZFP36L2|ERF2|RNF162C|TIS11D
Gene ID
678
UniProt
P47974
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Zinc finger protein 36, C3H type-like 2
Target
ZFP36L2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
51 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Frequently Asked Questions
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