TP63 antibody
Product Specifications
Background
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Synonyms
Tumor protein 63 (p63) |Chronic ulcerative stomatitis protein (CUSP) |Keratinocyte transcription factor KET|Transformation-related protein 63 (TP63) |Tumor protein p73-like (p73L) |p40|p51|TP63|KET|P63|P73H|P73L|TP73L
Gene ID
8626
UniProt
Q9H3D4
Host
Mouse
Reactivity
Human
Immunogen
Tumor protein p63
Target
TP63
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB
Field of Research
Cancer
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
68 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
2A3
Tested Applications
ELISA, WB
Immunogen Sequence
381-680aa
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