SCN5A antibody
Product Specifications
Background
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.
Synonyms
Sodium channel protein type 5 subunit alpha|Sodium channel protein cardiac muscle subunit alpha|Sodium channel protein type V subunit alpha|Voltage-gated sodium channel subunit alpha Nav1.5|hH1|SCN5A
Gene ID
6331
UniProt
Q14524
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
sodium channel, voltage-gated, type V, alpha subunit
Target
SCN5A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
227 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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