NUMBL antibody
Product Specifications
Background
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Synonyms
Numb-like protein|Numb-related protein (Numb-R)|NUMBL
Gene ID
9253
UniProt
Q9Y6R0
Host
Mouse
Reactivity
Human
Immunogen
numb homolog(Drosophila)-like
Target
NUMBL
Clonality
Monoclonal
Isotype
IgG2a
Clone
8E0
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Developmental biology
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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