CD3 Antibody [17A2]
Product Specifications
Background
The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains gamma, delta, and epsilon subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 epsilon chain.
NCBI Gene ID
12501
Swiss Prot
P22646
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
17A2
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-220
Fragment
Rat IgG2b, kappa
Specificity
The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation.
Symbol
Cd3e
NCBI Official Name
CD3 antigen, epsilon polypeptide
NCBI Organism
Mus musculus
Background Reference 01
Miescher, G. C., Schreyer, M., MacDonald, H. R. (1989) . Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex.Immunology letters,23 (2), 113-118.
Background Reference 02
Mysliwietz, J., Thierfelder, S. (1992) . Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient.Blood,80 (10), 2661-2667.
Background Reference 03
Wu, L., Antica, M., Johnson, G. R., Scollay, R., Shortman, K. (1991) . Developmental potential of the earliest precursor cells from the adult mouse thymus.The Journal of experimental medicine,174 (6), 1617-1627.
Other Product Names
CD3, T3e, AI504783, CD3epsilon, Cd3e
Tested Applications
Flow, Functional Assays, IHC, IP
Physical Properties
Liquid
Curated Selection
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