ERLIN1 antibody
Product Specifications
Background
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) . Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618) .
Synonyms
Erlin-1|Endoplasmic reticulum lipid raft-associated protein 1|Protein KE04|Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1 (SPFH domain-containing protein 1) |ERLIN1|C10orf69|KE04|KEO4|SPFH1
Gene ID
10613
UniProt
O75477
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
ER lipid raft associated 1
Target
ERLIN1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
39 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP, IF
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