CXCR3-specific antibody
Product Specifications
Background
CXCR3 (C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells (PMID: 16847335) . CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury (PMID: 17250586) . Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4 (PMID:12782716) . This monoclonal antibody is specific to CXCR3B.
Synonyms
C-X-C chemokine receptor type 3 (CXC-R3, CXCR-3) |CKR-L2|G protein-coupled receptor 9|Interferon-inducible protein 10 receptor (IP-10 receptor) |CXCR3|GPR9
Gene ID
2833
UniProt
P49682
Host
Mouse
Reactivity
Human
Immunogen
Chemokine (C-X-C motif) receptor 3
Target
CXCR3
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB
Field of Research
Stem Cells, Immunology, Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa+43 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
6F7
Tested Applications
ELISA, WB
Immunogen Sequence
Peptide (N-terminal, extracellular domain)
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