CEP290 antibody
Product Specifications
Background
Studies in the Chlamydomonas model system has shown that the ciliary protein CEP290 is a critical component of these Y-link junctions. Additionally, numerous studies have demonstrated that CEP290’s function is critical for IFT—in CEP290 knockdown experiments, many proteins that would normally localize to the cilium fail to do so, and cilium formation is disrupted or absent. Mutations in CEP290 are accountable for cases of nephronophthisis, Leber congenital amaurosis and Joubert syndrome. In IF analtsis of HeLa cells, the white arrows show centrosome and cilium staining.
Synonyms
Centrosomal protein of 290 kDa (Cep290) |Bardet-Biedl syndrome 14 protein|Cancer/testis antigen 87 (CT87) |Nephrocystin-6|Tumor antigen se2-2|CEP290|BBS14|KIAA0373|NPHP6
Gene ID
80184
UniProt
O15078
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Centrosomal protein 290kDa
Target
CEP290
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP, IHC, IF
Field of Research
Cell Division, Proliferation, cancer
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
290 kDa, 150-180 kDa, 80 kDa, 60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP, IHC, IF
Curated Selection
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