NSC668036

NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 μM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1].

Product Specifications

CAS Number

[144678-63-7]

Product Name Alternative

21-desDFZ

UNSPSC

12352211

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nsc668036.html

Purity

99.9

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : ≥ 5mg/mL

Smiles

C[C@@H](C(O[C@@H](C(C)C)C(N[C@@H](C)C(O[C@@H](C(C)C)C(O)=O)=O)=O)=O)NC(OC(C)(C)C)=O

Molecular Formula

C21H36N2O9

Molecular Weight

460.52

References & Citations

[1]Jufang Shan, et al. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry. 2005 Nov 29;44 (47) :15495-503.|[2]Cong Wang, et al. Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp Cell Res. 2015 Feb 1;331 (1) :115-122.