Cyclo (Arg-Gly-Asp-D-Phe-Val) (TFA)
Cyclo (Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo (RGDfV) (TFA) ) is an integrin αvβ3 inhibitor. Cyclo (Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo (Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia[1].
Product Specifications
CAS Number
199807-33-5
Product Name Alternative
Cyclo (RGDfV) (TFA) ; C (RGDfV) (TFA)
UNSPSC
12352209
Target
Apoptosis; Integrin
Type
Peptides
Related Pathways
Apoptosis; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cyclo_Arg-Gly-Asp-D-Phe-Val__TFA.html
Purity
99.40
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC(CNC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC1=O)=O)=O)=O)CC(O)=O)N[C@@H]1CC2=CC=CC=C2.FC(C(O)=O)(F)F
Molecular Formula
C28H39F3N8O9
Molecular Weight
688.65
References & Citations
[1]Shen ZH, et al. Targeting of the leukemia microenvironment by c (RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12 (5) :3278-3284.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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