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Netropsin (dihydrochloride)

Product Specifications

UNSPSC Description

Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei[1]. Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus[4].

Target Antigen

Antibiotic; Bacterial; DNA/RNA Synthesis; Influenza Virus; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection;Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/netropsin-dihydrochloride.html

Purity

99.92

Solubility

DMSO : 125 mg/mL (ultrasonic)|H2O : 20 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(NC(CNC(N)=N)=O)=CN1C)NC2=CN(C)C(C(NCCC(N)=N)=O)=C2.[H]Cl.[H]Cl

Molecular Weight

503.39

References & Citations

[1]Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090(1):52-60.|[2]Grant MA, et al. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J. 2009 Feb 15;418(1):103-12.|[3]Mishra K et al. Netropsin, a minor groove binding ligand: a potential radioprotective agent. Radiat Res. 2009 Dec;172(6):698-705.|[4]Smee DF, et, al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-N6800A/Netropsin-dihydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-N6800A/Netropsin-dihydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

18133-22-7

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