Dicoumarol

Dicoumarol is an inhibitor of both NAD (P) H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 μM, respectively.

Product Specifications

CAS Number

[66-76-2]

Product Name Alternative

Dicumarol

UNSPSC

12352005

Hazard Statement

H301, H372, H401, H411

Target

PDHK; Quinone Reductase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dicoumarol.html

Purity

99.89

Solubility

DMSO : 3.67 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; adjust pH to 11 with NaOH)

Smiles

O=C1C(CC2=C(C3=CC=CC=C3OC2=O)O)=C(C4=CC=CC=C4O1)O

Molecular Formula

C19H12O6

Molecular Weight

336.29

Precautions

H301, H372, H401, H411

References & Citations

[1]Bian J, et al. Affinity-based small fluorescent probe for NAD (P) H:quinone oxidoreductase 1 (NQO1) . Design, synthesis and pharmacological evaluation. Eur J Med Chem. 2017 Feb 15;127:828-839.|[2]Zhang W, et al. Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells. PLoS One. 2017 Jun 15;12 (6) :e0179672.|[3]Fiorillo M, et al. Mitochondrial "power" drives tamoxifen resistance: NQO1 and GCLC are new therapeutic targets in breast cancer. Oncotarget. 2017 Mar 2;8 (12) :20309-20327.