Anti-Hu CD226 PE-Cy™7

CD226 is a type I transmembrane glycoprotein, which is expressed after activation on NK cells, platelets, monocytes, and some T cells. Its expression is increased in patients suffering from some autoimmune diseases or viral infections. CD226 is being phosphorylated on its cytoplasmic tail and interacts with LFA-1 complex (CD11a/CD18), resulting in calcium-independent intercellular contacts. Ligands for CD226 are CD155 and CD112.

Product Specifications

Certification

RUO

Reactivity

Non-human primates, Human

Target Antigen

CD226

Clone

11A8

Applications

FC (QC tested)

Format

PE-Cy

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Fourcade J, Sun Z, Chauvin JM, Ka M, Davar D, Pagliano O, Wang H, Saada S, Menna C, Amin R, Sander C, Kirkwood JM, Korman AJ, Zarour HM: CD226 opposes TIGIT to disrupt Tregs in melanoma. JCI Insight. 2018 Jul 26;3 (14) :e121157. , URL: https://pubmed.ncbi.nlm.nih.gov/30046006/, *Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M: Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155) . J Immunol. 2004 Apr 1;172 (7) :3994-8., URL: https://pubmed.ncbi.nlm.nih.gov/15034010/, *Deuss FA, Watson GM, Goodall KJ, Leece I, Chatterjee S, Fu Z, Thaysen-Andersen M, Andrews DM, Rossjohn J, Berry R: Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1. J Biol Chem. 2019 Aug 16;294 (33) :12534-12546., URL: https://pubmed.ncbi.nlm.nih.gov/31253644/, *Deng C, Li W, Fei Y, Wang L, Chen Y, Zeng X, Zhang F, Li Y: Imbalance of the CD226/TIGIT immune checkpoint is involved in the pathogenesis of primary biliary cholangitis. Front Immunol. 2020 Jul 24;11:1619., URL: https://pubmed.ncbi.nlm.nih.gov/32793241/