Clemizole

Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole is an inhibitor of TRPC5 channel. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 μM.

Product Specifications

CAS Number

[442-52-4]

UNSPSC

12352005

Target

HCV; HCV Protease; Histamine Receptor; TRP Channel

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Clemizole.html

Concentration

10mM

Purity

98.42

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C=C1)CN2C(CN3CCCC3)=NC4=CC=CC=C24

Molecular Formula

C19H20ClN3

Molecular Weight

325.84

References & Citations

[1]Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26 (9) :1019-27|[2]Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86 (5) :514-21|[3]Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344 (2) :388-96.