Pan-Trk-IN-3
Pan-Trk-IN-3 (Compound 11g) is a potent inhibitor of pan-Trk and their drug-resistant mutants with IC50 values of 2, 3, 2, 21, 26, 5, 7 and 6 nM against TrkA, TrkB, TrkC, TrkAG595R, TrkAG667C, TrkAG667S, TrkAF589L and TrkCG623R, respectively. Pan-Trk-IN-3 displays excellent antitumor activity and induces apoptosis[1].
Product Specifications
CAS Number
2763637-66-5
UNSPSC
12352005
Target
Apoptosis; Trk Receptor
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-trk-in-3.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(NC(NC2=CC(C(C)(C)C)=NN2C3=CC=C(C=C3)Cl)=O)=CC=C1NC4=C5OC(C)(C(NC5=NC=N4)=O)C
Molecular Formula
C29H31ClN8O3
Molecular Weight
575.06
References & Citations
[1]Pan S, et al. Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4- (phenylamino) -6H-pyrimido[5,4-b][1,4]oxazin-7 (8H) -one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants. J Med Chem. 2022 Feb 10;65 (3) :2035-2058.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkB; TrkC
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