Pertussis Toxin
Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins[1][2][3].
Product Specifications
CAS Number
70323-44-3
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Pertussis_Toxin.html
Purity
99.0
Solubility
10 mM in DMSO
Precautions
H302, H315, H319, H335
References & Citations
[1]Carbonetti NH, et al. Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools. Future Microbiol. 2010 Mar;5 (3) :455-69.|[2]Petronila Penela, et al. G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J. 2008 Apr 23;27 (8) :1206-18.|[3]Nicholas H Carbonetti, et al. Contribution of pertussis toxin to the pathogenesis of pertussis disease. Pathog Dis. 2015 Nov;73 (8) :ftv073.
Shipping Conditions
Isolate blue ice and the product with bubble pack to avoid direct contact
Storage Conditions
Store at 4°C, do not freeze
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Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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