Umbellulone
Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1].
Product Specifications
CAS Number
546-78-1
UNSPSC
12352211
Hazard Statement
H302
Target
TRP Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/umbellulone.html
Purity
99.60
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1[C@@]2(C(C)C)C[C@@]2([H])C(C)=C1
Molecular Formula
C10H14O
Molecular Weight
150.22
Precautions
H302
References & Citations
[1]Nassini R, et al. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain. 2012 Feb;135 (Pt 2) :376-90.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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