Umbellulone

Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1].

Product Specifications

CAS Number

[546-78-1]

UNSPSC

12352211

Hazard Statement

H302

Target

TRP Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/umbellulone.html

Purity

99.60

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1[C@@]2(C(C)C)C[C@@]2([H])C(C)=C1

Molecular Formula

C10H14O

Molecular Weight

150.22

Precautions

H302

References & Citations

[1]Nassini R, et al. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain. 2012 Feb;135 (Pt 2) :376-90.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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