PUMA rabbit pAb
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],
Product Specifications
Background
Synonyms
BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis
Gene ID
27113
UniProt
Q9BXH1
Cellular Locus
Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB IF, ELISA
Validated Applications
WB IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.
Molecular Weight
23kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES3285-1.pdf
Observed Molecular Weight
23 kD
Subcellular Location
Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release.
Other Product Names
BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis
Gene ID (Human)
27113
SwissProt (Human)
Q9BXH1
Available Sizes
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