Setipafant

Setipafant is a platelet-activating factor (PAF) antagonist.

Product Specifications

CAS Number

[132418-35-0]

Product Name Alternative

BN-50727

UNSPSC

12352005

Target

Platelet-activating Factor Receptor (PAFR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Setipafant.html

Solubility

10 mM in DMSO

Smiles

O=C(N(C1)CCC2=C1SC3=C2C(C4=CC=CC=C4Cl)=NCC5=NN=C(C)N53)NC6=CC=C(OC)C=C6

Molecular Formula

C26H23ClN6O2S

Molecular Weight

519.02

References & Citations

[1]de Boissieu D, et al. Effect of BN 50727 on pathological findings and tissue platelet activating factor levels during ileal ischemia in newborn piglets. J Pediatr Surg. 1996 Dec;31 (12) :1675-9.|[2]Filep JG, et al. Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor. Br J Pharmacol. 1992 Apr;105 (4) :912-8.