Exoenzyme C3, clostridium botulinum

Exoenzyme C3, clostridium botulinum, is a mono-ADP-ribosylating enzyme. Exoenzyme C3, clostridium botulinum specifically modifies RhoA, B, and C by transferring ADP-ribose to them, thereby inactivating these GTPases. Exoenzyme C3, clostridium botulinum can induce neuronal axonal and dendritic growth, inhibit macrophage migration, and regulate cytoskeletal dynamics. Exoenzyme C3, clostridium botulinum can be used in the research of spinal cord injury and diabetic painful neuropathy[1][2][3][4][5].

Product Specifications

CAS Number

[58319-92-9]

UNSPSC

12352204

Target

Biochemical Assay Reagents; ROCK

Type

Enzyme

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Others; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/exoenzyme-c3-clostridium-botulinum.html

Solubility

10 mM in DMSO

Smiles

[ExoenzymeC3,clostridiumbotulinum]

References & Citations

[1]Ingo Just, et al. Therapeutic Effects of Clostridium Botulinum C3 Exoenzyme. Naunyn Schmiedebergs Arch Pharmacol. 2011 Mar;383 (3) :247-52.|[2]Rotsch J, et al. Inhibition of macrophage migration by C. botulinum exoenzyme C3. Naunyn Schmiedebergs Arch Pharmacol. 2012 Sep;385 (9) :883-90. |[3]Muetzelburg MV, et al. Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 1;877 (13) :1344-51. |[4]Schröder A, et al. Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme. J Proteome Res. 2015 Nov 6;14 (11) :4721-33. |[5]Ohsawa M, et al. RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice. Pain. 2011 Jan;152 (1) :114-122.