Anti-Histone H3 pan H3F3A Rabbit Monoclonal Antibody, Clone#RM188

Boster Bio Anti-Histone H3 pan H3F3A Rabbit Monoclonal Antibody, Clone#RM188 (Catalog # M06819-28) . Tested in WB, ICC. ELISA, Luminex applications. This antibody reacts with Vertebrates.

Product Specifications

Synonyms

Histone H3.3; H3F3A; H3.3A, H3F3; PP781; H3F3B; H3.3B

Gene Name

H3F3A

UniProt

P84243

Host

Rabbit

Reactivity

Vertebrates

Cross Reactivity

This antibody reacts to all Histone H3 proteins, independent of post-translational modifications. No cross-reactivity with other histone proteins.

Immunogen

A peptide corresponding to the C-terminus of human Histone H3

Clonality

Monoclonal

Clone

Clone: RM188

Applications

WB, ICC, ELISA, Luminex

Field of Research

2339, Epigenetics and Nuclear Signaling, Histones

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

1 mg/mL

Form

Liquid

Function

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.