PDE5-IN-6c

PDE5-IN-6c is a potent and selective phosphodiesterase 5A1 (PDE5A1) inhibitor with the potential to inhibit Alzheimer's disease (AD) . PDE5-IN-6c exhibits an excellent in vitro IC50 (0.056 nM), demonstrating its potent inhibitory activity. PDE5-IN-6c has improved water solubility, making it a more attractive drug candidate[1].

Product Specifications

CAS Number

[1448419-13-3]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pde5-in-6c.html

Smiles

N#CC1=CC=C2N=C3CCN(CC3=C(C2=C1)NCC4=CC=C(C(Cl)=C4)OC)C(C)=O

Molecular Formula

C23H21ClN4O2

Molecular Weight

420.89

References & Citations

[1]Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease