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Anti-GPR120 FFAR4 Antibody

Boster Bio Anti-GPR120 FFAR4 Antibody (Catalog# A19859) . Tested in WB, IF, ICC, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

O3FAR1; GPR120; GPR129; PGR4; Omega-3 fatty acid receptor 1; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4

Gene Name

FFAR4

UniProt

Q5NUL3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human GPR120. Immunogen sequence location: 221 - 270

Clonality

Polyclonal

Tissue Specificity

Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas.

Applications

WB, IF, ICC, ELISA

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Receptor for medium and long-chain free fatty acids (FFAs) . Signals via a G (q) /G (11) -coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2) /TAB1-dependent effect, but independent of the G (q) /G (11) -coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

Molecular Weight

42241 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Free fatty acid receptor 4

Subcellular Location

Cell membrane; Multi-pass membrane protein. Colocalized with ARRB2 following DHA treatment.

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