Recombinant Human TIMP3 protein (His tag)
Product Specifications
Background
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Abbreviation
TIMP3
Synonyms
HSMRK222; K222TA2; MIG 5 protein; Metalloproteinase inhibitor 3; SFD; TIMP 3; TIMP-3; Tissue Inhibitor of Metalloproteinase 3
UniProt
P35625
Accession Number
P35625
Expression System
E.coli
Tag
N-His
Sequence
Cys 24-Asn 144
Field of Research
Signal Transduction; Cardiovascular; Cancer; Cell Biology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
13.2 kDa
Observed Molecular Weight
15 kDa
Species
Human
Available Sizes
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