Anti-Hu CD307c PE
CD307c is a type I transmembrane glycoprotein of the Fc receptor family. It contains both ITAM and ITIM motifs in its cytoplasmic domain. CD307c is expressed on the surface of NK cells, and T, Treg, B and plasma cell subsets. It seems to play a role in the regulation of immune response. Defects in CD307c function can result in autoimmune diseases, e.g. rheumatoid arthritis or systemic lupus erythematosus.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
DNA-immunization followed by a boost with CD307c transfected cells
Target Antigen
CD307c
Clone
H5
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Jourdan M, Robert N, Cren M, Thibaut C, Duperray C, Kassambara A, Cogné M, Tarte K, Klein B, Moreaux J: Characterization of human FCRL4-positive B cells. PLoS One. 2017 Jun 21;12 (6) :e0179793., URL: https://www.ncbi.nlm.nih.gov/pubmed/28636654, *Wysocka M, Kossenkov AV, Benoit BM, Troxel AB, Singer E, Schaffer A, Kim B, Dentchev T, Nagata S, Ise T, Showe LC, Rook AH: CD164 and FCRL3 are highly expressed on CD4+CD26- T cells in Sézary syndrome patients. J Invest Dermatol. 2014 Jan;134 (1) :229-236., URL: https://www.ncbi.nlm.nih.gov/pubmed/23792457, *Nagata S, Ise T, Pastan I: Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009 Jun 15;182 (12) :7518-26, URL: https://www.ncbi.nlm.nih.gov/pubmed/19494275
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody H5 recognizes an epitope within extracellular part of CD307c, a transmembrane glycoprotein expressed mainly on NK cells, and T and B cell subsets.
Applications Notes
6
Isotype
Mouse IgG2b kappa
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Rabbit Monoclonal Antibody [Clone ID: RM400]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
