ATB-343
ATB-343 is a derivative of Indomethacin that releases H2S. H2S has cytoprotective and anti-inflammatory effects, inhibiting leukocyte adhesion to vascular endothelium and leukocyte migration to inflammatory sites. ATB-343 can be used to suppress respiratory infections[1][2].
Product Specifications
CAS Number
1000700-26-4
UNSPSC
12352005
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/atb-343.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1=C(C)N(C(C2=CC=C(C=C2)Cl)=O)C3=C1C=C(C=C3)OC)OC4=CC=C(C(SS5)=CC5=S)C=C4
Molecular Formula
C28H20ClNO4S3
Molecular Weight
566.11
References & Citations
[1]Li M, et al. Syntheses, toxicities and anti-inflammation of H2S-donors based on non-steroidal anti-inflammatory drugs. Eur J Med Chem. 2017 Sep 29;138:51-65.|[2]Methods for treating viral infections using hydrogen sulfide (H2S) donors. United States, US20160058779 A1 2016-03-03.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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