What is the catalog number for KDM1B Antibody?

The catalog number for KDM1B Antibody is 7535.

What sizes are available for KDM1B Antibody?

KDM1B Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does KDM1B Antibody come in?

KDM1B Antibody is available in 2 different pack sizes.

Is KDM1B Antibody in stock?

KDM1B Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

KDM1B Antibody

Product Specifications

Background

Flavin-dependent histone demethylases regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (reviewed in 1) . KDM1B is a recently identified histone H3K4 demethylase that is required to establish maternal genomic imprints; targeted disruption of the KDM1B gene in mice led to lethality in their embryos, suggesting demethylation of H3K4 is critical for establishing the DNA methylation imprints (2) . KDM1B has also been shown to play a role in the transcription elongation in several genes (3) .

NCBI Gene ID

221656

Swiss Prot

Q8NB78

Accession Number

NP_694587

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

KDM1B antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1204 - K562 Cell Lysate

Concentration

1 mg/mL

Buffer

KDM1B antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KDM1B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

KDM1B antibody is human, mouse and rat reactive. At least two isoforms of KDM1B are known to exist; this KDM1B antibody will detect both isoforms.

Symbol

KDM1B

NCBI Official Name

Lysine (K) -specific demethylase 1B

NCBI Organism

Homo sapiens

Background Reference 01

Culhane JC and Cole PA. LSD1 and the chemistry of histone demethylation. Curr. Opin. Chem. Biol. 2007; 11:561-8.

Background Reference 02

Ciccone DN, Su H, Hevi S, et al. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature 2009; 461:415-8.

Background Reference 03

Fang R, Barbera A, Xu Y, et al. Human LSD2/KDM1b/AOF1 regulates genes transcription by modulating intragenic H3K4me2 methylation. Mol. Cell 2010; 39:222-233.

Other Product Names

KDM1B Antibody: AOF1, LSD2, C6orf193, bA204B7.3, dJ298J15.2, AOF1, Lysine-specific histone demethylase 1B, Flavin-containing amine oxidase domain-containing protein 1