DBCO-PEG3-acid
DBCO-PEG3-acid is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG3-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1].
Product Specifications
CAS Number
[2754384-59-1]
UNSPSC
12352005
Target
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-peg3-acid.html
Purity
98.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(CCOCCOCCOCCNC(CCC(N(C1)C2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O)=O)=O
Molecular Formula
C28H32N2O7
Molecular Weight
508.56
References & Citations
[1]Shih-Hsien Chuang, et al. Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof. WO2021248048A2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
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