(S) -SNAP5114

(S) -SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S) -SNAP5114 is an anticonvulsant agent[1][2].

Product Specifications

CAS Number

[157604-55-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-snap5114.html

Purity

98.09

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1CN(CCOC(C2=CC=C(OC)C=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)CCC1)O

Molecular Formula

C30H35NO6

Molecular Weight

505.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Borden LA, et al. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels. 1994;2 (3) :207-13.|[2]Borden LA, et al. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem Int. 1996 Oct;29 (4) :335-56.