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CDK4/6-IN-2

CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1].

Product Specifications

CAS Number

1800506-48-2

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk4-6-in-2.html

Purity

99.67

Solubility

DMSO : 5.2 mg/mL (ultrasonic)

Smiles

CCN1CCN(CC2=CN=C(NC3=NC=C(F)C(C4=CC(N(C(C)C)C(C)=N5)=C5C(F)=C4)=C3)N=C2)CC1

Molecular Formula

C27H32F2N8

Molecular Weight

506.59

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Frank Wu, et al. Kinase inhibitor and use thereof. US20180000819A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK4; CDK6

Available Sizes

Frequently Asked Questions

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