Hypaconitine
Product Specifications
UNSPSC Description
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism.
IC50 value:
Target:
In vitro: The present study investigated the metabolism of hypaconitine in vitro using male human liver microsomes. The primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6 and CYP2E1 [1].
In vivo:
Target Antigen
TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Hypaconitine.html
Purity
99.49
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CO[C@@H](CC1)C23[C@@](C[C@@]4(O)[C@@H]5OC(C6=CC=CC=C6)=O)([H])[C@@]5([H])[C@](OC(C)=O)([C@@H](O)[C@@H]4OC)C7C2N(C)C[C@@]1(COC)[C@@]3([H])[C@H]7OC
Molecular Weight
615.71
References & Citations
[1]Ling Ye, et al. Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species. Toxicology letters, 2011, 204 (1): 81-91|[2]Yang Yuan, et al. Difference of hypaconitine concentration in serum between cold-deficiency and normal mice. China Journal of Chinese Materia Medica, 2010-15|[3]Zhang Jinming, Compatibility Effect between Radix Aconiti Lateralis and Radix Glycyrrhizae on Pharmacokinetics of Hypaconitine in Rat Plasma by LC-MS/MS. World Science Technology-Modernization of Traditional Chinese Medicine, 2011-06
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0267/Hypaconitine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0267/Hypaconitine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
6900-87-4
Available Sizes
Curated Selection
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