UP158
UP158 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 2.57 μM[1].
Product Specifications
CAS Number
489402-33-7
UNSPSC
12352005
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/up158.html
Purity
99.88
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=CC2=C(NC3=C(N4CCC5(CC4)OCCO5)N=CN=C32)C=C1
Molecular Formula
C17H17ClN4O2
Molecular Weight
344.80
References & Citations
[1]Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134 (14) :e169039.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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