RO4929097

RO4929097 (RG-4733) is an orally active γ secretase inhibitor with an IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively[1].

Product Specifications

CAS Number

[847925-91-1]

Product Name Alternative

RG-4733

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Notch; γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/RO4929097.html

Purity

99.01

Solubility

DMSO : ≥ 49 mg/mL

Smiles

O=C(C(C)(C(NCC(F)(C(F)(F)F)F)=O)C)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O

Molecular Formula

C22H20F5N3O3

Molecular Weight

469.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Luistro L, et al. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res. 2009, 69 (19), 7672-7680.|[2]Debeb BG, et al. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells. Breast Cancer Res Treat. 2012.|[3]Huynh C, et al. The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma. PLoS One. 2011, 6 (9), e25264.