JG-231

JG-231 is an allosteric inhibitor of heat shock protein 70 (Hsp70) . JG - 231 inhibits the binding of Hsp70 and BAG family proteins, including inhibition of Hsp70 and BAG1 with a Ki of 0.11 μM. JG-231 inhibits proliferation of tumor cells and induces apoptosis. JG-231 has antitumor activity[1][2].

Product Specifications

CAS Number

[1627126-59-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; HSP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jg-231.html

Purity

98.47

Solubility

DMSO : 2 mg/mL (ultrasonic)

Smiles

O=C1N(CC)/C(S/C1=C2SC3=CC(Cl)=CC=C3N/2C)=C/C4=[N+](CC5=CC=C(Br)S5)C=CS4.[Cl-]

Molecular Formula

C22H18BrCl2N3OS4

Molecular Weight

619.47

Precautions

H302, H315, H319

References & Citations

[1]Shao H, et al. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70) . J Med Chem. 2018 Jul 26;61 (14) :6163-6177. |[2]Hong SK, et al. Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells. Int J Mol Sci. 2022 Jan 19;23 (3) :1063.