Trifluridine

Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors[1][2][3][4].

Product Specifications

CAS Number

[70-00-8]

Product Name Alternative

Trifluorothymidine; 5-Trifluorothymidine; TFT

UNSPSC

12352005

Hazard Statement

H341, H351, H361

Target

Apoptosis; Autophagy; DNA/RNA Synthesis; HSV; Nucleoside Antimetabolite/Analog; Orthopoxvirus; Thymidylate Synthase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Trifluorothymidine.html

Purity

99.98

Solubility

DMSO : ≥ 100 mg/mL|H2O : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1C[C@H](N2C(NC(C(C(F)(F)F)=C2)=O)=O)O[C@@H]1CO

Molecular Formula

C10H11F3N2O5

Molecular Weight

296.20

Precautions

H341, H351, H361

References & Citations

[1]Okayama T, et al. Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J Pharmacol Exp Ther. 2012 Feb;340 (2) :457-62.|[2]Jia HJ, et al. Trifluridine induces HUVECs senescence by inhibiting mTOR-dependent autophagy. Biochem Biophys Res Commun. 2022 Jun 25;610:119-126.|[3]Suzuki N, et al. Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer. Oncol Lett. 2017 Jul;14 (1) :639-646.|[4]Li J, et al. Trifluridine selectively inhibits cell growth and induces cell apoptosis of triple-negative breast cancer. Am J Cancer Res. 2020 Feb 1;10 (2) :507-522.