MGluR5 antagonist-1

MGluR5 antagonist-1 is an orally active mGluR5 antagonist with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect. mGluR5 antagonist-1 can be used for the study of depressive disorder[1].

Product Specifications

CAS Number

[2761424-76-2]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mglur5-antagonist-1.html

Purity

98.80

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CN1C2=NC=NC(C#CC3=CC=CC=C3)=C2C=C1C(NC4=CC=C(OC)C=C4)=O

Molecular Formula

C23H18N4O2

Molecular Weight

382.41

References & Citations

[1]Yonglei Du, et al. Novel substituted 4- (Arylethynyl) -Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice. Eur J Med Chem. 2023.