LMA2L Rabbit Polyclonal Antibody

This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins| which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains| which display homology to leguminous lectins. Unlike other proteins of the group| which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes| the protein encoded by this gene is a non-cycling resident protein of the ER| where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway.