DAD1 Rabbit Polyclonal Antibody

DAD1| the defender against apoptotic cell death| was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature| suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme| thus reflecting the essential nature of N-linked glycosylation in eukaryotes.