PKC delta Recombinant Rabbit mAb
Product Specifications
Background
Calcium-independent, phospholipid- and diacylglycerol (DAG) -dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis.
CAS Number
9000-83-3
Structure Composition
Store at -20°C. Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Product Name Alternative
Pkcd; PKC[d]; AI385711; PKCdelta; D14Ertd420e
Swiss Prot
P28867
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human PKC delta
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, FC
Purity
Affinity Purification
Modification
Unmodification
Molecular Weight
78 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG
Applications Notes
Western blot detection of PKC delta in K562, C6,3T3 cell lysates using PKC delta antibody (1:1000 diluted) .
Host or Source
Rabbit
Available Sizes
Curated Selection
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