TGS1 polyclonal antibody

Product Specifications

Background

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m (7G caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m (2,2,7G cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs. Plays a role in transcriptional regulation.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

TGS1; NCOA6IP; PIMT; PIPMT

Swiss Prot

Q96RS0

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human TGS1 (NP_079107.6) .

Conjugation

Unconjugated

Applications

Dilution

WB,1:500 - 1:2000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .