Retsat (NM_026159) Mouse Recombinant Protein

Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol (PubMed:15358783, PubMed:17253779, PubMed:19139408) . Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers (PubMed:15358783) . May play a role in the metabolism of vitamin A (PubMed:15358783, PubMed:17253779) . Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP (PubMed:28855500) . Required for adipocyte differentiation in a 3T3-L1 cell culture model (PubMed:19139408) . This effect seems not to mimic the in vivo situation in which animals show increased adiposity in the absence of RETSAT (PubMed:19940255) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Purified recombinant protein of Mouse retinol saturase (all trans retinol 13, 14 reductase) (Retsat), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug