LMO3 polyclonal antibody

Product Specifications

Background

LMO3 (LIM domain only 3), also known as RBTN3 (Rhombotin-3), RBTNL2 or RHOM3, is a 145 amino acid protein that contains two LIM zinc-binding domains and may be involved in transcriptional regulation events in tissues throughout the body. Aberrant expression of LMO3 is associated with the genesis and progression of human neuroblastoma, suggesting a role for LMO3 in oncogenesis. The gene encoding LMO3 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

LIM domain only protein 3; LMO-3; Neuronal-specific transcription factor DAT1; Rhombotin-3

Swiss Prot

Q8TAP4

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 101-145 of Human LMO3.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 20 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

LMO3 polyclonal antibody detects endogenous levels of LMO3 protein.

Applications Notes

Western blot (WB) analysis of LMO3 polyclonal antibody at 1:500 dilution Lane1:SK-OVCAR3 whole cell lysate (40ug) Lane2:HEK293T whole cell lysate (40ug) Lane3:THP-1 whole cell lysate (40ug) Lane4:AML-12 whole cell lysate (40ug) Lane5:PC12 whole cell lysate (40ug)