Integrin αV (P804) polyclonal antibody
Product Specifications
Background
The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) .Several αV subfamily members, including αVβ3, αVβ5, αVβ1, are highly expressed in active endothelial cells and cancer cells where they play a critical role in angiogenesis and tumor metastasis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Integrin alpha-V; Vitronectin receptor subunit alpha; CD51; Integrin alpha-V heavy chain; Integrin alpha-V light chain; ITGAV; MSK8; VNRA
Swiss Prot
P06756
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 771-820 of Human Integrin αV.
Conjugation
Unconjugated
Related Pathways
Tumor Angiogenesis, Contribution of ECM and Cytoskeletal Factors to EMT
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 116 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Integrin αV (P804) polyclonal antibody detects endogenous levels of Integrin αV protein.
Applications Notes
Western blot (WB) analysis of Integrin αV (P804) pAb at 1:1000 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:C6 whole cell lysate (20ug) Lane3:CT26 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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