PCDH15 polyclonal antibody
Product Specifications
Background
PCDH15 (protocadherin 15), also known as USH1F or DFNB23, is a 1,955 amino acid single-pass type I membrane protein that contains 11 cadherin domains and exists as multiple alternatively spliced isoforms. Expressed in testis, brain, lung, kidney and spleen, PCDH15 functions as a calcium-dependent cell-adhesion protein that is crucial for the maintenance of normal cochlear and retinal function. Defects in the gene encoding PCDH15 are associated with Usher syndrome type 1F (USH1F), Usher syndrome type 1D/F (USH1DF) and non-syndromic sensorineural deafness autosomal recessive type 23 (DFNB23), all of which are associated with deafness. Multiple isoforms of PCDH15 exist due to alternative splicing events.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
USH1F; Protocadherin-15; Protocadherin 15
Swiss Prot
Q96QU1
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human PCDH15.
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB 1:2000 - 1:5000 IHC 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 100 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PCDH15 polyclonal antibody detects endogenous levels of PCDH15 protein.
Applications Notes
Western blot analysis of extracts of various cells, using PCDH15 antibody.
Host or Source
Rabbit
Available Sizes
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