NKX2-4 polyclonal antibody
Product Specifications
Background
TTF-1 (thyroid transcription factor-1, BCH, BHC, NK-2, Nkx2.1, Nkx2A, TEBP, TTF1) is a member of the Nkx2 family of homeodomain-containing transcription factors and regulates the transcriptional activity of thyroid-specific genes. TTF-1 influences organogenisis and the maintenance of the differentiated phenotypes of various tissues including thyroid, lung and brain. TTF-1, which is present in the epithelium of the lung, regulates transcription of the surfactant proteins (SP) A, B and C and is essential for lung morphogenesis. In the thyroid, TTF-1 elevates the expression of thyroid specific markers, thyroglobulin, thyroperoxidase and thyrotropin receptors. TTF-1 interacts with SRC-1 and CBP in vitro.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Homeobox protein Nkx-2.4; Homeobox protein NK-2 homolog D; NKX2-4; NKX2D
Swiss Prot
Q9H2Z4
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human NKX2-4.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 36 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
NKX2-4 polyclonal antibody detects endogenous levels of NKX2-4 protein.
Applications Notes
Western blot (WB) analysis of NKX2-4 polyclonal antibody at 1:500 dilution LaneA:MCF-7 whole cell lysate LaneB:H1792 whole cell lysate LaneC:PC12 whole cell lysate LaneD:CT-26 whole cell lysate
Host or Source
Rabbit
Available Sizes
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